Publications

2024

Kundu, S., Paul, B., Reuevni, I., Lamprecht, R. and Barkai, E. (2024). Learning-induced bidirectional enhancement of inhibitory synaptic metaplasticity. J Physiol. https://doi.org/10.1113/JP284761

2023

Awasthi, R., Yuan, Q., & Barkai, E. (2023). Reversing Aging: Decline in Complex Olfactory Learning Can be Rectified by Restoring Intrinsic Plasticity of Hippocampal CA1 Pyramidal Neurons. Advanced biology, e2300323. Advance online publication. https://doi.org/10.1002/adbi.202300323

2022

Jabarin, R., Dagash, W., Netser, S., Singh, S., Paul, B. K., Barkai, E., & Wagner, S. (2022). Modulation of social investigation by anterior hypothalamic nucleus rhythmic neural activity. iScience, 26(2), 105921. https://doi.org/10.1016/j.isci.2022.105921

Ilovich, O., Dines, M., Paul, B. K., Barkai, E., & Lamprecht, R. (2022). Nck1 activity in lateral amygdala regulates long-term fear memory formation. Translational psychiatry, 12(1), 475. https://doi.org/10.1038/s41398-022-02244-x

Awasthi, R., Chandra, N., & Barkai, E. (2022). Olfactory rule learning-induced enhancement in intrinsic neuronal excitability is maintained by shutdown of the cholinergic M-current. Frontiers in cellular neuroscience, 16, 934838. https://doi.org/10.3389/fncel.2022.934838

2021

Kumar, A., Barkai, E., & Schiller, J. (2021). Plasticity of olfactory bulb inputs mediated by dendritic NMDA-spikes in rodent piriform cortex. eLife, 10, e70383. https://doi.org/10.7554/eLife.70383

Paul, B. K., Barkai, E., & Lamprecht, R. (2021). The role of p21-activated kinase in maintaining the fear learning-induced modulation of excitation/inhibition ratio in lateral amygdala. Neurobiology of learning and memory, 179, 107385. https://doi.org/10.1016/j.nlm.2021.107385

2020

Ma, X., Zhang, Y., Wang, L., Li, N., Barkai, E., Zhang, X., Lin, L., & Xu, J. (2020). The Firing of Theta State-Related Septal Cholinergic Neurons Disrupt Hippocampal Ripple Oscillations via Muscarinic Receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(18), 3591–3603. https://doi.org/10.1523/JNEUROSCI.1568-19.2020

Kfir, A., Awasthi, R., Ghosh, S., Kundu, S., Paul, B., Lamprecht, R., & Barkai, E. (2020). A Cellular Mechanism of Learning-Induced Enhancement of Synaptic Inhibition: PKC-Dependent Upregulation of KCC2 Activation. Scientific reports, 10(1), 962. https://doi.org/10.1038/s41598-020-57626-2

Paul, B. K., Reuveni, I., Barkai, E., & Lamprecht, R. (2020). Learning-induced enduring changes in inhibitory synaptic transmission in lateral amygdala are mediated by p21-activated kinase. Journal of neurophysiology, 123(1), 178–190. https://doi.org/10.1152/jn.00559.2019

Chandra, N., Awasthi, R., Ozdogan, T., Johenning, F. W., Imbrosci, B., Morris, G., Schmitz, D., & Barkai, E. (2019). A Cellular Mechanism Underlying Enhanced Capability for Complex Olfactory Discrimination Learning. eNeuro, 6(1), ENEURO.0198-18.2019. https://doi.org/10.1523/ENEURO.0198-18.2019

2019

2018

Kumar, A., Schiff, O., Barkai, E., Mel, B. W., Poleg-Polsky, A., & Schiller, J. (2018). NMDA spikes mediate amplification of inputs in the rat piriform cortex. eLife, 7, e38446. https://doi.org/10.7554/eLife.38446

Reuveni, I., & Barkai, E. (2018). Tune it in: mechanisms and computational significance of neuron-autonomous plasticity. Journal of neurophysiology, 120(4), 1781–1795. https://doi.org/10.1152/jn.00102.2018

Reuveni, I., Lin, L., & Barkai, E. (2018). Complex-learning Induced Modifications in Synaptic Inhibition: Mechanisms and Functional Significance. Neuroscience, 381, 105–114. https://doi.org/10.1016/j.neuroscience.2018.04.023

Jammal, L., Whalley, B., & Barkai, E. (2018). Learning-induced modulation of the effect of neuroglial transmission on synaptic plasticity. Journal of neurophysiology, 119(6), 2373–2379. https://doi.org/10.1152/jn.00101.2018

Chandra, N., & Barkai, E. (2018). A non-synaptic mechanism of complex learning: Modulation of intrinsic neuronal excitability. Neurobiology of learning and memory, 154, 30–36. https://doi.org/10.1016/j.nlm.2017.11.015

Ghosh, S., Reuveni, I., Zidan, S., Lamprecht, R., & Barkai, E. (2018). Learning-induced modulation of the effect of endocannabinoids on inhibitory synaptic transmission. Journal of neurophysiology, 119(2), 752–760. https://doi.org/10.1152/jn.00623.2017

Reuveni, I., Ghosh, S., & Barkai, E. (2017). Real Time Multiplicative Memory Amplification Mediated by Whole-Cell Scaling of Synaptic Response in Key Neurons. PLoS computational biology, 13(1), e1005306. https://doi.org/10.1371/journal.pcbi.1005306

2017

2016

Jammal, L., Whalley, B., Ghosh, S., Lamrecht, R., & Barkai, E. (2016). Physiological expression of olfactory discrimination rule learning balances whole-population modulation and circuit stability in the piriform cortex network. Physiological reports, 4(14), e12830. https://doi.org/10.14814/phy2.12830

Zhang, L., Ma, X., Chen, G., Barkai, E., & Lin, L. (2016). Theta Rhythmic Clock-Like Activity of Single Units in the Mouse Hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(16), 4415–4420. https://doi.org/10.1523/JNEUROSCI.3851-15.2016

Ghosh, S., Reuveni, I., Barkai, E., & Lamprecht, R. (2016). Calcium/calmodulin-dependent kinase II activity is required for maintaining learning-induced enhancement of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated synaptic excitation. Journal of neurochemistry, 136(6), 1168–1176. https://doi.org/10.1111/jnc.13505

Ghosh, S., Reuveni, I., Lamprecht, R., & Barkai, E. (2015). Persistent CaMKII activation mediates learning-induced long-lasting enhancement of synaptic inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(1), 128–139. https://doi.org/10.1523/JNEUROSCI.2123-14.2015

2015

Cohen, Y., Wilson, D. A., & Barkai, E. (2015). Differential modifications of synaptic weights during odor rule learning: dynamics of interaction between the piriform cortex with lower and higher brain areas. Cerebral cortex (New York, N.Y. : 1991), 25(1), 180–191. https://doi.org/10.1093/cercor/bht215

2014

Barkai, E., & Wilson, D. A. (2014). Odor memory and perception. Preface. Progress in brain research, 208, ix–x. https://doi.org/10.1016/B978-0-444-63350-7.10000-2

Barkai E. (2014). Neural mechanisms of odor rule learning. Progress in brain research, 208, 253–274. https://doi.org/10.1016/B978-0-444-63350-7.00010-3

Kfir, A., Ohad-Giwnewer, N., Jammal, L., Saar, D., Golomb, D., & Barkai, E. (2014). Learning-induced modulation of the GABAB-mediated inhibitory synaptic transmission: mechanisms and functional significance. Journal of neurophysiology, 111(10), 2029–2038. https://doi.org/10.1152/jn.00004.2014

Motanis, H., Maroun, M., & Barkai, E. (2014). Learning-induced bidirectional plasticity of intrinsic neuronal excitability reflects the valence of the outcome. Cerebral cortex (New York, N.Y. : 1991), 24(4), 1075–1087. https://doi.org/10.1093/cercor/bhs394

Reuveni, I., Saar, D., & Barkai, E. (2013). A novel whole-cell mechanism for long-term memory enhancement. PloS one, 8(7), e68131. https://doi.org/10.1371/journal.pone.0068131

2013

Saar, D., Reuveni, I., & Barkai, E. (2012). Mechanisms underlying rule learning-induced enhancement of excitatory and inhibitory synaptic transmission. Journal of neurophysiology, 107(4), 1222–1229. https://doi.org/10.1152/jn.00356.2011

2012

Cohen, Y., Avramoav, S., Barkai, E., & Maroun, M. (2011). Olfactory learning-induced enhancement of the predisposition for LTP induction. Learning & memory (Cold Spring Harbor, N.Y.), 18(9), 594–597. https://doi.org/10.1101/lm.2231911

2011

Cohen-Matsliah, S. I., Motanis, H., Rosenblum, K., & Barkai, E. (2010). A novel role for protein synthesis in long-term neuronal plasticity: maintaining reduced postburst afterhyperpolarization. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(12), 4338–4342. https://doi.org/10.1523/JNEUROSCI.5005-09.2010

2010

2009

Cohen-Matsliah, S. I., Rosenblum, K., & Barkai, E. (2009). Olfactory-learning abilities are correlated with the rate by which intrinsic neuronal excitability is modulated in the piriform cortex. The European journal of neuroscience, 30(7), 1339–1348. https://doi.org/10.1111/j.1460-9568.2009.06894.x

Brosh, I., & Barkai, E. (2009). Learning-induced enhancement of feedback inhibitory synaptic transmission. Learning & memory (Cold Spring Harbor, N.Y.), 16(7), 413–416. https://doi.org/10.1101/lm.1430809

Saar, D., & Barkai, E. (2009). Long-lasting maintenance of learning-induced enhanced neuronal excitability: mechanisms and functional significance. Molecular neurobiology, 39(3), 171–177. https://doi.org/10.1007/s12035-009-8060-5

Liraz, O., Rosenblum, K., & Barkai, E. (2009). CAMKII activation is not required for maintenance of learning-induced enhancement of neuronal excitability. PloS one, 4(1), e4289. https://doi.org/10.1371/journal.pone.0004289

Cohen-Matsliah, S. I., Seroussi, Y., Rosenblum, K., & Barkai, E. (2008). Persistent ERK activation maintains learning-induced long-lasting modulation of synaptic connectivity. Learning & memory (Cold Spring Harbor, N.Y.), 15(10), 756–761. https://doi.org/10.1101/lm.1127008

2008

Cohen, Y., Reuveni, I., Barkai, E., & Maroun, M. (2008). Olfactory learning-induced long-lasting enhancement of descending and ascending synaptic transmission to the piriform cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(26), 6664–6669. https://doi.org/10.1523/JNEUROSCI.0178-08.2008

Naimark, A., Barkai, E., Michael, M. A., Kozlovsky, N., Kaplan, Z., & Cohen, H. (2008). Olfactory learning prevents MK-801-induced psychosis-like behaviour in an animal model of schizophrenia. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 9(2), 135–146. https://doi.org/10.1080/15622970701286528

Brosh, I., Rosenblum, K., & Barkai, E. (2007). Learning-induced modulation of SK channels-mediated effect on synaptic transmission. The European journal of neuroscience, 26(11), 3253–3260. https://doi.org/10.1111/j.1460-9568.2007.05936.x

2007

Cohen-Matsliah, S. I., Brosh, I., Rosenblum, K., & Barkai, E. (2007). A novel role for extracellular signal-regulated kinase in maintaining long-term memory-relevant excitability changes. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(46), 12584–12589. https://doi.org/10.1523/JNEUROSCI.3728-07.2007

Naimark, A., Barkai, E., Matar, M. A., Kaplan, Z., Kozlovsky, N., & Cohen, H. (2007). Upregulation of neurotrophic factors selectively in frontal cortex in response to olfactory discrimination learning. Neural plasticity, 2007, 13427. https://doi.org/10.1155/2007/13427

Lebel, D., Sidhu, N., Barkai, E., & Quinlan, E. M. (2006). Learning in the absence of experience-dependent regulation of NMDAR composition. Learning & memory (Cold Spring Harbor, N.Y.), 13(5), 566–570. https://doi.org/10.1101/lm.276606

2006

Brosh, I., Rosenblum, K., & Barkai, E. (2006). Learning-induced reversal of the effect of noradrenalin on the postburst AHP. Journal of neurophysiology, 96(4), 1728–1733. https://doi.org/10.1152/jn.00376.2006

2005

Barkai E. (2005). Dynamics of learning-induced cellular modifications in the cortex. Biological cybernetics, 92(6), 360–366. https://doi.org/10.1007/s00422-005-0564-0

Knafo, S., Libersat, F., & Barkai, E. (2005). Olfactory learning-induced morphological modifications in single dendritic spines of young rats. The European journal of neuroscience, 21(8), 2217–2226. https://doi.org/10.1111/j.1460-9568.2005.04041.x

Knafo, S., Libersat, F., & Barkai, E. (2005). Dynamics of learning-induced spine redistribution along dendrites of pyramidal neurons in rats. The European journal of neuroscience, 21(4), 927–935. https://doi.org/10.1111/j.1460-9568.2005.03936.x

Knafo, S., Barkai, E., Libersat, F., Sandi, C., & Venero, C. (2005). Dynamics of olfactory learning-induced up-regulation of L1 in the piriform cortex and hippocampus. The European journal of neuroscience, 21(2), 581–586. https://doi.org/10.1111/j.1460-9568.2005.03862.x

Knafo, S., Barkai, E., Herrero, A. I., Libersat, F., Sandi, C., & Venero, C. (2005). Olfactory learning-related NCAM expression is state, time, and location specific and is correlated with individual learning capabilities. Hippocampus, 15(3), 316–325. https://doi.org/10.1002/hipo.20052

2004

Brosh, I., & Barkai, E. (2004). Learning-induced long-term synaptic modifications in the olfactory cortex. Current neurovascular research, 1(4), 389–395. https://doi.org/10.2174/1567202043362090

Knafo, S., Ariav, G., Barkai, E., & Libersat, F. (2004). Olfactory learning-induced increase in spine density along the apical dendrites of CA1 hippocampal neurons. Hippocampus, 14(7), 819–825. https://doi.org/10.1002/hipo.10219

Quinlan, E. M., Lebel, D., Brosh, I., & Barkai, E. (2004). A molecular mechanism for stabilization of learning-induced synaptic modifications. Neuron, 41(2), 185–192. https://doi.org/10.1016/s0896-6273(03)00874-2

Saar, D., & Barkai, E. (2003). Long-term modifications in intrinsic neuronal properties and rule learning in rats. The European journal of neuroscience, 17(12), 2727–2734. https://doi.org/10.1046/j.1460-9568.2003.02699.x

2003

2002

Seroussi, Y., Brosh, I., & Barkai, E. (2002). Learning-induced reduction in post-burst after-hyperpolarization (AHP) is mediated by activation of PKC. The European journal of neuroscience, 16(5), 965–969. https://doi.org/10.1046/j.1460-9568.2002.02155.x

Saar, D., Grossman, Y., & Barkai, E. (2002). Learning-induced enhancement of postsynaptic potentials in pyramidal neurons. Journal of neurophysiology, 87(5), 2358–2363. https://doi.org/10.1152/jn.2002.87.5.2358