Publications

2025

Daphne D, Ahire A, Singh SP, Wagner S, Barkai E, Reuveni I. (2025) Extended fear learning enhances excitatory and inhibitory synaptic transmission onto amygdala engram cells. Nat Commun. doi: 10.1038/s41467-025-64854-5.

2024

Kundu, S., Paul, B., Reuevni, I., Lamprecht, R. and Barkai, E. (2024). Learning-induced bidirectional enhancement of inhibitory synaptic metaplasticity. J Physiol. https://doi.org/10.1113/JP284761

2023

Awasthi, R., Yuan, Q., & Barkai, E. (2023). Reversing Aging: Decline in Complex Olfactory Learning Can be Rectified by Restoring Intrinsic Plasticity of Hippocampal CA1 Pyramidal Neurons. Advanced biology, e2300323. Advance online publication. https://doi.org/10.1002/adbi.202300323

2022

Jabarin, R., Dagash, W., Netser, S., Singh, S., Paul, B. K., Barkai, E., & Wagner, S. (2022). Modulation of social investigation by anterior hypothalamic nucleus rhythmic neural activity. iScience, 26(2), 105921. https://doi.org/10.1016/j.isci.2022.105921

Ilovich, O., Dines, M., Paul, B. K., Barkai, E., & Lamprecht, R. (2022). Nck1 activity in lateral amygdala regulates long-term fear memory formation. Translational psychiatry, 12(1), 475. https://doi.org/10.1038/s41398-022-02244-x

Awasthi, R., Chandra, N., & Barkai, E. (2022). Olfactory rule learning-induced enhancement in intrinsic neuronal excitability is maintained by shutdown of the cholinergic M-current. Frontiers in cellular neuroscience, 16, 934838. https://doi.org/10.3389/fncel.2022.934838

2021

Kumar, A., Barkai, E., & Schiller, J. (2021). Plasticity of olfactory bulb inputs mediated by dendritic NMDA-spikes in rodent piriform cortex. eLife, 10, e70383. https://doi.org/10.7554/eLife.70383

Paul, B. K., Barkai, E., & Lamprecht, R. (2021). The role of p21-activated kinase in maintaining the fear learning-induced modulation of excitation/inhibition ratio in lateral amygdala. Neurobiology of learning and memory, 179, 107385. https://doi.org/10.1016/j.nlm.2021.107385

2020

Ma, X., Zhang, Y., Wang, L., Li, N., Barkai, E., Zhang, X., Lin, L., & Xu, J. (2020). The Firing of Theta State-Related Septal Cholinergic Neurons Disrupt Hippocampal Ripple Oscillations via Muscarinic Receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(18), 3591–3603. https://doi.org/10.1523/JNEUROSCI.1568-19.2020

Kfir, A., Awasthi, R., Ghosh, S., Kundu, S., Paul, B., Lamprecht, R., & Barkai, E. (2020). A Cellular Mechanism of Learning-Induced Enhancement of Synaptic Inhibition: PKC-Dependent Upregulation of KCC2 Activation. Scientific reports, 10(1), 962. https://doi.org/10.1038/s41598-020-57626-2

Paul, B. K., Reuveni, I., Barkai, E., & Lamprecht, R. (2020). Learning-induced enduring changes in inhibitory synaptic transmission in lateral amygdala are mediated by p21-activated kinase. Journal of neurophysiology, 123(1), 178–190. https://doi.org/10.1152/jn.00559.2019

Chandra, N., Awasthi, R., Ozdogan, T., Johenning, F. W., Imbrosci, B., Morris, G., Schmitz, D., & Barkai, E. (2019). A Cellular Mechanism Underlying Enhanced Capability for Complex Olfactory Discrimination Learning. eNeuro, 6(1), ENEURO.0198-18.2019. https://doi.org/10.1523/ENEURO.0198-18.2019

2019

2018

Kumar, A., Schiff, O., Barkai, E., Mel, B. W., Poleg-Polsky, A., & Schiller, J. (2018). NMDA spikes mediate amplification of inputs in the rat piriform cortex. eLife, 7, e38446. https://doi.org/10.7554/eLife.38446

Reuveni, I., & Barkai, E. (2018). Tune it in: mechanisms and computational significance of neuron-autonomous plasticity. Journal of neurophysiology, 120(4), 1781–1795. https://doi.org/10.1152/jn.00102.2018

Reuveni, I., Lin, L., & Barkai, E. (2018). Complex-learning Induced Modifications in Synaptic Inhibition: Mechanisms and Functional Significance. Neuroscience, 381, 105–114. https://doi.org/10.1016/j.neuroscience.2018.04.023

Jammal, L., Whalley, B., & Barkai, E. (2018). Learning-induced modulation of the effect of neuroglial transmission on synaptic plasticity. Journal of neurophysiology, 119(6), 2373–2379. https://doi.org/10.1152/jn.00101.2018

Chandra, N., & Barkai, E. (2018). A non-synaptic mechanism of complex learning: Modulation of intrinsic neuronal excitability. Neurobiology of learning and memory, 154, 30–36. https://doi.org/10.1016/j.nlm.2017.11.015

Ghosh, S., Reuveni, I., Zidan, S., Lamprecht, R., & Barkai, E. (2018). Learning-induced modulation of the effect of endocannabinoids on inhibitory synaptic transmission. Journal of neurophysiology, 119(2), 752–760. https://doi.org/10.1152/jn.00623.2017

Reuveni, I., Ghosh, S., & Barkai, E. (2017). Real Time Multiplicative Memory Amplification Mediated by Whole-Cell Scaling of Synaptic Response in Key Neurons. PLoS computational biology, 13(1), e1005306. https://doi.org/10.1371/journal.pcbi.1005306

2017

2016

Jammal, L., Whalley, B., Ghosh, S., Lamrecht, R., & Barkai, E. (2016). Physiological expression of olfactory discrimination rule learning balances whole-population modulation and circuit stability in the piriform cortex network. Physiological reports, 4(14), e12830. https://doi.org/10.14814/phy2.12830

Zhang, L., Ma, X., Chen, G., Barkai, E., & Lin, L. (2016). Theta Rhythmic Clock-Like Activity of Single Units in the Mouse Hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(16), 4415–4420. https://doi.org/10.1523/JNEUROSCI.3851-15.2016

Ghosh, S., Reuveni, I., Barkai, E., & Lamprecht, R. (2016). Calcium/calmodulin-dependent kinase II activity is required for maintaining learning-induced enhancement of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated synaptic excitation. Journal of neurochemistry, 136(6), 1168–1176. https://doi.org/10.1111/jnc.13505

Ghosh, S., Reuveni, I., Lamprecht, R., & Barkai, E. (2015). Persistent CaMKII activation mediates learning-induced long-lasting enhancement of synaptic inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(1), 128–139. https://doi.org/10.1523/JNEUROSCI.2123-14.2015

2015

Cohen, Y., Wilson, D. A., & Barkai, E. (2015). Differential modifications of synaptic weights during odor rule learning: dynamics of interaction between the piriform cortex with lower and higher brain areas. Cerebral cortex (New York, N.Y. : 1991), 25(1), 180–191. https://doi.org/10.1093/cercor/bht215

2014

Barkai, E., & Wilson, D. A. (2014). Odor memory and perception. Preface. Progress in brain research, 208, ix–x. https://doi.org/10.1016/B978-0-444-63350-7.10000-2

Barkai E. (2014). Neural mechanisms of odor rule learning. Progress in brain research, 208, 253–274. https://doi.org/10.1016/B978-0-444-63350-7.00010-3

Kfir, A., Ohad-Giwnewer, N., Jammal, L., Saar, D., Golomb, D., & Barkai, E. (2014). Learning-induced modulation of the GABAB-mediated inhibitory synaptic transmission: mechanisms and functional significance. Journal of neurophysiology, 111(10), 2029–2038. https://doi.org/10.1152/jn.00004.2014

Motanis, H., Maroun, M., & Barkai, E. (2014). Learning-induced bidirectional plasticity of intrinsic neuronal excitability reflects the valence of the outcome. Cerebral cortex (New York, N.Y. : 1991), 24(4), 1075–1087. https://doi.org/10.1093/cercor/bhs394

Reuveni, I., Saar, D., & Barkai, E. (2013). A novel whole-cell mechanism for long-term memory enhancement. PloS one, 8(7), e68131. https://doi.org/10.1371/journal.pone.0068131

2013

Saar, D., Reuveni, I., & Barkai, E. (2012). Mechanisms underlying rule learning-induced enhancement of excitatory and inhibitory synaptic transmission. Journal of neurophysiology, 107(4), 1222–1229. https://doi.org/10.1152/jn.00356.2011

2012

Cohen, Y., Avramoav, S., Barkai, E., & Maroun, M. (2011). Olfactory learning-induced enhancement of the predisposition for LTP induction. Learning & memory (Cold Spring Harbor, N.Y.), 18(9), 594–597. https://doi.org/10.1101/lm.2231911

2011

Cohen-Matsliah, S. I., Motanis, H., Rosenblum, K., & Barkai, E. (2010). A novel role for protein synthesis in long-term neuronal plasticity: maintaining reduced postburst afterhyperpolarization. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(12), 4338–4342. https://doi.org/10.1523/JNEUROSCI.5005-09.2010

2010

2009

Cohen-Matsliah, S. I., Rosenblum, K., & Barkai, E. (2009). Olfactory-learning abilities are correlated with the rate by which intrinsic neuronal excitability is modulated in the piriform cortex. The European journal of neuroscience, 30(7), 1339–1348. https://doi.org/10.1111/j.1460-9568.2009.06894.x

Brosh, I., & Barkai, E. (2009). Learning-induced enhancement of feedback inhibitory synaptic transmission. Learning & memory (Cold Spring Harbor, N.Y.), 16(7), 413–416. https://doi.org/10.1101/lm.1430809

Saar, D., & Barkai, E. (2009). Long-lasting maintenance of learning-induced enhanced neuronal excitability: mechanisms and functional significance. Molecular neurobiology, 39(3), 171–177. https://doi.org/10.1007/s12035-009-8060-5

Liraz, O., Rosenblum, K., & Barkai, E. (2009). CAMKII activation is not required for maintenance of learning-induced enhancement of neuronal excitability. PloS one, 4(1), e4289. https://doi.org/10.1371/journal.pone.0004289

Cohen-Matsliah, S. I., Seroussi, Y., Rosenblum, K., & Barkai, E. (2008). Persistent ERK activation maintains learning-induced long-lasting modulation of synaptic connectivity. Learning & memory (Cold Spring Harbor, N.Y.), 15(10), 756–761. https://doi.org/10.1101/lm.1127008

2008

Cohen, Y., Reuveni, I., Barkai, E., & Maroun, M. (2008). Olfactory learning-induced long-lasting enhancement of descending and ascending synaptic transmission to the piriform cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(26), 6664–6669. https://doi.org/10.1523/JNEUROSCI.0178-08.2008

Naimark, A., Barkai, E., Michael, M. A., Kozlovsky, N., Kaplan, Z., & Cohen, H. (2008). Olfactory learning prevents MK-801-induced psychosis-like behaviour in an animal model of schizophrenia. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 9(2), 135–146. https://doi.org/10.1080/15622970701286528

Brosh, I., Rosenblum, K., & Barkai, E. (2007). Learning-induced modulation of SK channels-mediated effect on synaptic transmission. The European journal of neuroscience, 26(11), 3253–3260. https://doi.org/10.1111/j.1460-9568.2007.05936.x

2007

Cohen-Matsliah, S. I., Brosh, I., Rosenblum, K., & Barkai, E. (2007). A novel role for extracellular signal-regulated kinase in maintaining long-term memory-relevant excitability changes. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(46), 12584–12589. https://doi.org/10.1523/JNEUROSCI.3728-07.2007

Naimark, A., Barkai, E., Matar, M. A., Kaplan, Z., Kozlovsky, N., & Cohen, H. (2007). Upregulation of neurotrophic factors selectively in frontal cortex in response to olfactory discrimination learning. Neural plasticity, 2007, 13427. https://doi.org/10.1155/2007/13427

Lebel, D., Sidhu, N., Barkai, E., & Quinlan, E. M. (2006). Learning in the absence of experience-dependent regulation of NMDAR composition. Learning & memory (Cold Spring Harbor, N.Y.), 13(5), 566–570. https://doi.org/10.1101/lm.276606

2006

Brosh, I., Rosenblum, K., & Barkai, E. (2006). Learning-induced reversal of the effect of noradrenalin on the postburst AHP. Journal of neurophysiology, 96(4), 1728–1733. https://doi.org/10.1152/jn.00376.2006

2005

Barkai E. (2005). Dynamics of learning-induced cellular modifications in the cortex. Biological cybernetics, 92(6), 360–366. https://doi.org/10.1007/s00422-005-0564-0

Knafo, S., Libersat, F., & Barkai, E. (2005). Olfactory learning-induced morphological modifications in single dendritic spines of young rats. The European journal of neuroscience, 21(8), 2217–2226. https://doi.org/10.1111/j.1460-9568.2005.04041.x

Knafo, S., Libersat, F., & Barkai, E. (2005). Dynamics of learning-induced spine redistribution along dendrites of pyramidal neurons in rats. The European journal of neuroscience, 21(4), 927–935. https://doi.org/10.1111/j.1460-9568.2005.03936.x

Knafo, S., Barkai, E., Libersat, F., Sandi, C., & Venero, C. (2005). Dynamics of olfactory learning-induced up-regulation of L1 in the piriform cortex and hippocampus. The European journal of neuroscience, 21(2), 581–586. https://doi.org/10.1111/j.1460-9568.2005.03862.x

Knafo, S., Barkai, E., Herrero, A. I., Libersat, F., Sandi, C., & Venero, C. (2005). Olfactory learning-related NCAM expression is state, time, and location specific and is correlated with individual learning capabilities. Hippocampus, 15(3), 316–325. https://doi.org/10.1002/hipo.20052

2004

Brosh, I., & Barkai, E. (2004). Learning-induced long-term synaptic modifications in the olfactory cortex. Current neurovascular research, 1(4), 389–395. https://doi.org/10.2174/1567202043362090

Knafo, S., Ariav, G., Barkai, E., & Libersat, F. (2004). Olfactory learning-induced increase in spine density along the apical dendrites of CA1 hippocampal neurons. Hippocampus, 14(7), 819–825. https://doi.org/10.1002/hipo.10219

Quinlan, E. M., Lebel, D., Brosh, I., & Barkai, E. (2004). A molecular mechanism for stabilization of learning-induced synaptic modifications. Neuron, 41(2), 185–192. https://doi.org/10.1016/s0896-6273(03)00874-2

Saar, D., & Barkai, E. (2003). Long-term modifications in intrinsic neuronal properties and rule learning in rats. The European journal of neuroscience, 17(12), 2727–2734. https://doi.org/10.1046/j.1460-9568.2003.02699.x

2003

2002

Seroussi, Y., Brosh, I., & Barkai, E. (2002). Learning-induced reduction in post-burst after-hyperpolarization (AHP) is mediated by activation of PKC. The European journal of neuroscience, 16(5), 965–969. https://doi.org/10.1046/j.1460-9568.2002.02155.x

Saar, D., Grossman, Y., & Barkai, E. (2002). Learning-induced enhancement of postsynaptic potentials in pyramidal neurons. Journal of neurophysiology, 87(5), 2358–2363. https://doi.org/10.1152/jn.2002.87.5.2358